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THE
BIOLOGICAL TREATMENTS FOR AUTISM AND PDD
Lecture Notes: William Shaw, PHD Nashville, TN; October 23, 1999 Note: These notes were taken in draft form and cannot be guaranteed for complete accuracy. They were written hurriedly and often have been paraphrased. For definitive information about the work and views of Dr. Shaw, please consult his book BIOLOGICAL TREAMENTS FOR AUTISM AND PDD, (William Shaw, Ph.D., 1998, ISBN 0-9661238-0-8). A big thanks! to Ken Weatherman, Ph.D., for compiling these notes! First
speaker: Dr. William Crook,
MD Dr. Crook spoke for a few minutes. He made special mention of a publication, A SPECIAL MESSAGE FOR THE HEALTH PROFESSIONAL. He suggested this publication as a reference for skeptical health professionals. Main speaker: Dr. William Shaw Many of the biological determinants apply across the spectrum of developmental disorders Frequent occurrence in medical history of otitis media (ear infections); these are treated with antibiotics which is a continuing scenario – then ADD, ADHD, PDD (?), autism; these often appear after the use of antibiotics Genetic
basis for autism: Risch,
N et al: Stanford University Autism Genetics Project
Case
study: identical male twins Recommendation: No immunization at the time of antibiotic treatments for infections Many more adverse metabolites have been found in the urines of children with autism; none of these metabolites was tied to any known genetic diseases Most of these compounds were from the intestinal tract, not from genetic origin (organic acids) Tartaric acid – characteristically elevated in autistic children There
is not a lot of research literature on tartaric acid –
not many articles (only about 12) Candida albicans: thrush (yeast infection – candida – in the mouth) In
the child with autism, regression after this scenario
as expressed above Nystatin – often used to treat candida infections Nystatin
and tartaric acid: The die off reaction can be quite severe Autistics
are very susceptible to being re-colonized with yeast
Immune
system defects in fighting candida: Note: Nystatin presents no long-term side effects or toxic effects Combining
drugs is a good idea if there are external manifestations
of yeast: One of the problems with treating yeast is the development of resistance due to the AIDS epidemic Cell-mediated
immunity – immunity occurring in the actual cells
A key point: anti-fungal treatment had significant benefit Tartaric
acid is an analog – implications for Kreb’s cycle metabolism
Recommends:
Acidophilus GG with Nystatin After
two months: increased focus and concentration Summary
of tartaric acid: Healthy people have 1-2 pounds of bacteria growing in the gastrointestinal tract at any one time Antibiotics mess up the ecology of the gastrointestinal tract Drug resistant organisms have given rise to the proliferation of antibiotics Feed
animals are given antibiotics – more food to animals –
no microorganisms in the gut to reduce available feeds
to animals Some people choose free range meat – more expensive, less fatty, may be tougher, but will not contain antibiotics Low muscle tone in autistic children is almost universal – hypotonia – fits the theory of toxins from yeast impairing muscular energy supply Is autism a brain disease or a more systemic disease? All organs may be affected. We have previously focused primarily on behavior 90% of individuals with autism have elevated antibiotics to milk and wheat Sugars have a tremendous impact on yeast growth Sugars cause a great increase in yeast production – (200 times more yeast in mice receiving sugars compared with mice receiving plain water Yeast is not the problem, but too much yeast is the problem The younger the animal becomes affected with yeast, the more chronic the problem Ear infections are most often caused by food allergies One antibiotic can cause this problem – one single use, yet severe yeast problems can occur with a person having no antibiotic treatments Testing:
The urine test does not test for yeast directly, but for the byproducts of yeast Yeast
is involved in the fermentation of sugar into alcohol
Arabinose: Kiehn: SCIENCE: 206: 577, 1979 Arabinose:
Candida
breaks down the intestinal lining – food allergies – “leaky
gut syndrome” Lysine
reaction with Arabinose – proteins limited in function
to some degree (cross linkages of proteins) Alzheimer’s – autism link Blockage
of biotin, vitamin B6 and lipoic acid – these compete
with Arabinose for receptor sites Vitamin
B6 needs to react at these sites In the case of identical twins with autism there was marked differences in symptoms with Arabinose elevated in the low functioning child There probably are genetic factors associated with tendencies for yeast infections Tissues
cross-reactive to candida antibodies (Vodjani, 48: 1-15,
1976; CLINICAL IMMUNOLOGY. Restrict apples and apple juice for 24 hours prior to urine test for organic acids because they contain Arabinose Look at apples or apple juice intake – look for sensitivity – a sugar reaction within minutes and an Arabinose reaction within 30 – 90 minutes. Anti-fungal
therapies:
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Cave
man diet: meat, fish, vegetables, eggs > almost never causes problems
with yeast overgrowth “If it is sweet, don’t eat” – even fruits may be a problem Milk, wheat, eggs, corn, sugar > these are among the most allergy-provoking of all foods, but eggs are a part of the cave man diet Arthritis – automatically think food allergy FEAST WITHOUT YEAST – a good resource Gluten and Casein Free Diet Link Complex carbohydrates are better than the simple sugars Ketogenic diet with people having seizures – extreme variant of cave man diet (no carbohydrates) Recommendation: Supernuthera which is high in vitamin B6 (Kirkman Labs); some do not tolerate this very well; recommends to experiment and increase gradually to find an optimal dose High Vitamin B6 may be as effective as Ritalin in controlling hyperactivity MCT
oil – medium chain triglycerides (found in health food stores;
often used by body builders) Anti-fungal
drugs Recommendation:
6 weeks Diflucan + Nystatin – continue with Nystatin for over
9 months Over the counter anti-fungals: (caprylic acid, caprylates; MCT oil; coconut oil; garlic; oregano; oral aloe Vera; goldenseal; pau d’arco; grapefruit seed extract; tanalbit (?) Yeast
die off reaction: symptoms: nausea; vomiting; extreme fatigue,
sleeping for 3-5 days; Silver works – proceed with caution (?) Using an over the counter with Nystatin is possible Ginger is also an anti-fungal Yeast will come back – this is a recurrent problem There are no good levels of Pb and Hg (lead and mercury, respectively) – even minute levels are too much in the body Glutathione – the body’s detoxifying chemical Can check food allergies behaviorally – give the food after deprivation to see if they fall apart Recommendation: remove food dyes from children with autism Tooth fillings: Hg fillings may not be a good idea for autistics Return samples of urine and blood by airborne express – transport cost is included in the price Doctors’ orders are required for the tests Factors leading to otitis media: overall immune deficiency Food allergy can cause ear infections: the most common cause There is a relationship between the number and severity of ear infections and the severity of autism Hyperacute
sound sensitivity Garlic and Mull oil for ear infections Allergies:
(pollens and molds, usually seasonal, usually related to outside;
food; molds; and chemicals or odors) Food
allergies – eliminate NAET.com – before and after blood and urine > see if it alters biochemistry Kleire
(?) labs: enzyme product called “serenade” Undigested food in the stool may man lack of enzymes, thus a need for enzyme supplementation Any food can be a source of food allergy Hawaiian punch – Red dye #40 – (nothing in this food that is red) IgA deficiency is about 80 times greater than that of normal children Many children with autism cannot absorb the vitamin A found in vitamin pills – recommends the old form which is cod liver oil or cod liver capsules Prism lenses for autistics – could this be related to Vitamin A? Toe walking – could this be the result of constipation? Might be symptomatic of severe constipation Could lack of eye contact be due to zinc deficiency? Depression, psychotic disorders, autism, ADD, chronic fatigue, fibromyalgia, PMS, infertility > may have some common features Secretin – stimulates the pancreas to release digestive enzymes (secretin is produced in the duodenum) The duodenum secretes CCK Pancreas: digestive enzymes, bicarbonate The duodenum produces secretin Bicarbonate – ½ teaspoon with meals has improved some autistic children (given with meals) CCK – helps the gall bladder to release bile Secretin – increases bicarbonate; increases digestive enzymes, increases tyrosine hydroxylase in the central nervous system, increases aldosterone secretion by the adrenals, modulates the immune system, (binds to receptors in the pancreas, kidney, small intestine, lung, and liver; binds to very small receptors in the brain, heart, and ovary) Secretin is an overall favorable treatment – 20% very good response; 20% no response; 60% moderate response Secretin helps regulate the pH Adverse characteristics of secretin – (severe yeast problem with major seizures; may cause auto antibodies against human and pig secretin; reduced immune response against common disease; increased hyperactivity, aggression, or self injurious behaviors, herpes-like outbreaks in the mouth) The long-term effects of secretin are not known Pig and human secretin each is composed of 27 amino acids. The are identical except for 2 differences in the amino acid chains; substitutions are very much alike Methods
of administering secretin: CCK-8-cholecystokinin
CCK
– health food stores CCK will increase vocalization, reduce digestive problems, improved sleep, increased imaginative play, increased focus and concentration; CCK’s results are equivalent to secretin’s; might be an alternative to secretin; can find CCK in a health food store May get same benefits from CCK as with secretin A guess: it would take maybe a month to see changes in behavioral situations Using Nystatin and restricting wheat and dairy products are benign treatments Epsom salts soaks: calming effect; also Mg (magnesium) sulfate may be absorbed during the bath to increase Mg in the body Mg supplement given with vitamin B6 to give the maximum benefit Kirkman people will direct and tell where to start dosage of vitamins Do
testing before beginning therapies Actions of CCK: (start release of digestive enzymes; gall bladder to release bicarbonate; overdose causes panic attacks, depression, aggression, and burning stools); implication: use CCK carefully GAME
– antibodies Abnormality of all GAME antibodies likely in the autistic Stimulants
for the immune system – particularly zinc and selenium
IV
gamma globulin – in vein on a monthly basis for 6-12 months
Do
not do IgE for food allergies Pizza – the self destruct food for children with autism For the control of yeast die off reaction give an enema Dihydroxyphenyl prorioic (?) does not respond to Nystatin (a phenylalanine derivative); similar in structure to dopamine and norepinephrine Gg acidophilus – killed this type of (?) Increased
dopamine can result in crazy behavior Effects of 3-hydroxytryosine in rats: hyperreactive; headweaving; backward walking; hyperactivity; wet dog shakes Effect
of clostridia on dopamine and norepinephrine metabolism (?)
IAG
– from tryptophan Casomorphine
(opiate peptides) Disruption of “energy fields”: acupressure Study with NAET: looking for parents with children who have been reactive to vaccinations EPD
(Enzyme Potentiated Desensitization) – many doctors have left
the Internet and have gone underground; work under Investigative
Review Board (under a “clinical trial,” considered experimental
Speaker: Dr. Furr Dr. Furr (Knoxville) – chronic fatigue and fibromyalgia Could alcoholism actually be a food allergy? “Any child that has had ear tubes has allergies. If before age 2, they have a food allergy.” Provocation neutralization – can occur in seconds <Environmental medicine> Starting points: 3 tests; will get recommendations with test results; additional consultations Wild Oats: source of foods Dr Bradstreet – how to do it (the order of doing things) Kleire(SP) Labs A Huge thanks to Ken Weatherman, Ph.D., for compiling these notes!
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